Chromosome Fragments have the Potential to Predict Hyperthermia - induced Radio - sensitization i Two Different Human Tumor Cell Lines
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چکیده
tion combined with fluorescent in situ hybridisation (PCC-FISH) has been shown to be clinically applicable. Therefore, the use of chromosomal aberrations as determined with PCC-FISH for the prediction of hyperthermia-induced radio-sensitization in human tumor cells was investigated. Confluent cultures of SW-1573 (human lung carcinoma) and RKO (human colorectat carcinoma) cells were treated with 1 h 4teC or 430C hyperthermia prior to virradiation. Clonogenic cell survival and induction of chromosomal aberrations
منابع مشابه
Chromosome fragments have the potential to predict hyperthermia-induced radio-sensitization in two different human tumor cell lines.
Cellular radiosensitivity, assessed by loss of clonogenicity, has been shown to correlate with the number of radiation-induced chromosomal aberrations. Also an increased radiosensitivity by hyperthermia has been shown to correlate with an increase in chromosomal aberrations. Therefore, determination of the number of chromosomal aberrations might be used as an assay to predict the radiosensitivi...
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تاریخ انتشار 2017